Such an improvement in sleep quality is related to the action of magnolia and agnus-castus extracts in addition to the decrease in hot flashes occurring during the night. As is well known, magnolia and agnus-castus have neurotrophic and anxiolytic properties, explaining the positive effect on symptoms such as irritability, melancholy, headache, and tiredness. A beneficial effect on these symptoms is associated with a better quality of sleep, in particular subjective sleep satisfaction, less nocturnal awakening and lower nightmare frequency.
The population taking the treatment showed better subjective sleep quality and an easier ability to fall asleep, resulting in a better quality of life as shown by the SF test results. This study has the advantage that a suitable number of patients were followed for an appropriate period of time so as to confer statistical significance to the results.
However, this study has its limits: the use of a single tablet containing a combination of magnolia, agnus-castus , vitamin D3 and Lactobacillus sporogenes in the ESP group did not elucidate the contribution that each individual component made to the end result. Further studies using even larger populations over longer periods of time with investigations of the individual components would be helpful.
In conclusion, agnus-castus and magnolia in combination with SI can effectively and safely be used in the treatment of vasomotor symptoms in postmenopausal women, especially when quality of sleep is the most disturbing complaint.
National Center for Biotechnology Information , U. Journal List Nutrients v. Published online Feb Author information Article notes Copyright and License information Disclaimer. Received Oct 27; Accepted Feb 3. This article has been cited by other articles in PMC. Abstract The effectiveness for vasomotor symptoms and sleep disorders plus the long-term safety of a nutraceutical combination of agnus-castus and magnolia extracts combined with soy isoflavones SI and lactobacilli were assessed in postmenopausal women.
Keywords: isoflavones, menopause management, endometrial thickness, mammary density, liver function, plant extracts. Introduction Sleep disturbances negatively affect the quality of life of postmenopausal women; almost half of all menopausal women complain of sleep disorders, frequently associated with hot flashes and mood disturbances [ 1 , 2 ]. Materials and Methods In a prospective, observational, controlled study, postmenopausal patients in non-hormonal treatment for menopausal vasomotor symptoms gave their informed consent to participate.
The treatment efficacy was evaluated at baseline and every three months by: a. Results The clinical features of patients enrolled in the study are reported in Table 1 according to the treatment group.
Table 1 Anamnestic and clinical features. Open in a separate window. Table 2 Safety profile. Figure 1. Figure 2. Discussion In the present study, a combination of 60 mg SI with Lactobacillus sporogenes , agnus-castus and magnolia was compared to SI alone. Conflicts of Interest The authors declare no conflict of interest.
References 1. Bruyneel M. Sleep disturbances in menopausal women: Aetiology and practical aspects. Examining the relationship between subjective sleep disturbance and menopause: A systematic review and meta-analysis. North American Menopause Society Estrogen and progestogen use in postmenopausal women: position statement of the North American Menopause Society.
Nonhormonal management of menopause-associated vasomotor symptoms: position statement of the North American Menopause Society. Rabin D. Why menopausal women do not want to take hormone replacement therapy.
Panay N. Integrating phytoestrogens with prescription medicines—A conservative clinical approach to vasomotor symptom management. Lethaby A. Phytoestrogens for vasomotor menopausal symptoms. Cochrane Database Syst. Pino A. Dietary isoflavones affect sex hormone-binding globulin levels in postmenopausal women. Colacurci N. I took agnus castus and didn't have an af for 3. I take AC as tablets on their own, and the SI are combined with my multivit the boots own brand ones.
My cycles have been getting shorter since I started and my moods are way more constant so I am going to continue as I am but in a few cycles time may try without the AC.
Join now to personalise. I just wanted to check if they can be taken with Agnus castus? Thanks ladies! Xxx Sent from my iPhone using Netmums. See last answer. I have read not to take the two together as it cancels on another out. I take ac this cycle, seems to have shortened my cycle by 10 days, hopefully I will get my bfp this month. Search for a thread. Been mentioned about angus n considering trying it. Where did yo uhh get it from? Trying for a baby Soy isoflavones.
I ordered it off the internet off a website called Natures Corner Ah I didn't realise they might cancel each other out! I'm going to continue with the Soy Isoflavones and then go with AC next month! And just keep alternating them until I get my BFP! A controlled study was carried-out in menopausal women comparing this nutraceutical combination ESP group with formulation containing isoflavones alone C group , at the dosage recommended.
Endometrial thickness, mammary density and liver function were evaluated at baseline and after 12 months. At the treatment end, mammary density, endometrial thickness, and hepatic function did not show substantial differences between groups.
Kuppermann index, and particularly hot flushes, were progressively and significantly decreased in frequency and severity during ESP versus C treatment. No adverse events were observed. Endometrium, mammary glands and liver function, were unaffected after 12 months treatment. Download PDF. Your full name. Your affiliation information e. Your Email address not made public. Importance: How significant is the paper to the field? Significant contribution. Incremental contribution. No contribution.
I am not qualified to judge.
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